The exact cause of non-segmental vitiligo is not fully understood, but it is believed to result from a combination of genetic, autoimmune, and environmental factors. Some possible causes and contributing factors include:

• Autoimmune Reaction: Non-segmental vitiligo is thought to occur due to an autoimmune reaction in which the body’s immune system mistakenly targets and destroys melanocytes, the pigment-producing cells in the skin.

• Genetic Predisposition: Genetic factors may play a role in the development of non-segmental vitiligo, as individuals with a family history of vitiligo or autoimmune diseases are more likely to develop the condition.

• Environmental Triggers: Environmental factors such as sun exposure, stress, trauma, or exposure to certain chemicals may trigger or exacerbate non-segmental vitiligo in susceptible individuals.